Tuesday, 18 January 2011

associated diseases with types of Acanthosis nigricans

Which of the following malignancies is associated with the skin condition in the photo?
  • A) Ovarian carcinoma
  • B) Gastric carcinoma
  • C) Malignant melanoma
  • D) Multiple myeloma
  • E) Hodgkin's lymphoma

The answer is B. (Acanthosis nigricans)
Acanthosis nigricans is associated with hyperpigmented areas that typically affect flexural folds (axilla). The two basic types of acanthosis nigricans are benign and malignant.
-The benign form is associated with obesity, diabetes, Stein-Leventhal syndrome, Cushing's disease, Addison's disease, pituitary disorders, and hyperandrogenic syndromes. Drugs, including glucocorticoids, nicotinic acid, diethylstilbestrol, and growth hormone therapy, have also caused acanthosis nigricans. Many cases are idiopathic.
-Malignant acanthosis nigricans is associated with an intestinal cancer such as gastric carcinoma.

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